A Guide to Sample Size for Animal-based Studies 1st Edition

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A Guide to Sample Size for Animal-based Studies: Ethical Experimental Design This book is an innovative, thorough, and accessible reference work that addresses the critical need to "rightsize" animal-based experiments . It provides a straightforward, systematic approach to sample size estimation based on the fundamentals of statistical thinking, helping researchers navigate the design trade-offs necessary to simultaneously minimize animal use and produce scientifically rigorous and reliable results. Key Features Ethical Framework (3Rs): The book addresses the principles of Replacement, Reduction, and Refinement , which comprise the ethical framework for humane animal-based studies, ensuring experiments are both ethical and scientifically valid. Step-by-Step Guidance: It offers step-by-step guidance in diverse methods for approximating and refining sample size, ensuring a clear and systematic process for experimental design. Specialized Research Topics: It provides detailed treatment of research topics specific to animal-based research, including pilot, feasibility, and proof-of-concept studies . Data and Study Types: The book covers sample size approximation methods for different types of data ( binary, continuous, ordinal, time to event ) and different study types ( description, comparison, nested designs, reference interval construction, and dose-response studies ). Practical Examples and Code: Includes numerous worked examples , using real data from published papers, together with SAS and R code , to facilitate application in research. Broad Audience: A must-have reference for preclinical and veterinary researchers , as well as ethical oversight committees and policymakers .

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